Daniel J. Fall, M.D.; Arthur B. French, M.D., F.A.C.P.; H. Marvin Pollard, M.D., F.A.C.P.
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The stimulus that triggers transmission of the sensation of esophageal pain is not well defined. In normal subjects distention of the lower esophagus with a balloon or sudden infusion of fluid produces pain, usually considered due to distention of the esophagus and production of motor activity. It is generally assumed that in the presence of an intact esophageal mucosa the "stretch" or "tension" stimulus is the only intraesophageal stimulus that produces pain. In patients with esophagitis, infusion of much smaller amounts of 0.1 N acid produces pain. This painful infusion is almost invariably accompanied by motor abnormalities. It is not
Fall DJ, French AB, Pollard HM. Esophageal Pain and Esophageal pH.. Ann Intern Med. 1967;66:1031. doi: https://doi.org/10.7326/0003-4819-66-5-1031_2
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Published: Ann Intern Med. 1967;66(5):1031.
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