Glenn D. Lubash, M.D., F.A.C.P.; Edith C. Hammel, B.A.; Rosalie J. Mearles, B.Sc.
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Decreased Pressor responsiveness to infusions of angiotensin in cirrhosis could be related to increased enzymatic destruction of angiotensin or to changes in the renin-angiotensin system: sodium depletion, increased renin (angiotensin), and secondary aldosteronism. Biron, Baldus, and Summerskill (Proc. Soc. Exp. Biol. Med. 116: 1074, 1964) found elevated plasma angiotensinase activity in cirrhotic patients by biological assay of degradation of angiotensin II amide added to plasma in vitro. Recent data of Nagatsu and associates (Biochem. Pharmacol. 14: 721 and 853, 1966), however, indicate that the hydrolysis of N-terminal amino acid residues from angiotensin and its amide is mediated by different enzymes,
Lubash GD, Hammel EC, Mearles RJ. Serum Angiotensinase and Plasma Renin Activity in Hepatic Insufficiency.. Ann Intern Med. ;66:1031–1032. doi: 10.7326/0003-4819-66-5-1031_3
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Published: Ann Intern Med. 1967;66(5):1031-1032.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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