Stephen M. Ayres, M.D., F.A.C.P.; John L. Penny, M.D.; Stanley Giannelli Jr., M.D.; Ruth G. Armstrong, R.N.
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Cigarette smoking and exposure to urban air pollution may raise carboxyhemoglobin (COHb) saturation to from 10 to 20%. Studies were performed on 20 subjects undergoing diagnostic cardiac catheterization and on 19 dogs to determine the effects of this concentration of COHb on alveolar gas exchange and on myocardial oxygen consumption. Arterial, mixed venous, and coronary sinus blood were sampled and analyzed for PO2, PCO2 and pH by electrochemical techniques. Oxygen and carbon monoxide contents were measured by gas chromatography. Coronary flow was measured by 131I aminopyrine using a modification of the original Kety saturation technique.
In contrast to accepted theory,
Ayres SM, Penny JL, Giannelli S, Armstrong RG. The Effects of Small Concentrations of Carboxyhemoglobin on Gas Exchange and Myocardial Oxygen Consumption.. Ann Intern Med. ;66:1033. doi: 10.7326/0003-4819-66-5-1033_2
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Published: Ann Intern Med. 1967;66(5):1033.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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