Keith E. Cohn, M.D.; J. Robert Stewart, M.D.; Luis F. Fajardo, M.D.; E. William Hancock, M.D., F.A.C.P.
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Twenty-five patients who developed heart disease after radiation therapy to the chest for malignant neoplasm have been studied. Twenty-three patients had pericardial disease, including acute pericarditis (15 cases), chronic pericardial effusion (12 cases), and chronic constrictive pericarditis (10 cases).
Pericardial effusion developed during an episode of acute pericarditis in 11 cases, and 6 patients had cardiac tamponade. The pericardial fluid was usually bloody, with a high protein content. Ten patients with acute pericarditis recovered, but five progressed to chronic constrictive pericardial disease. The chronic constrictive pericarditis occurred in association with chronic pericardial effusion (seven cases) and with myocardial fibrosis and
Cohn KE, Stewart JR, Fajardo LF, et al. Radiation Heart Disease.. Ann Intern Med. 1967;66:1035–1036. doi: 10.7326/0003-4819-66-5-1035_3
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Published: Ann Intern Med. 1967;66(5):1035-1036.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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