John J. Harris, M.D., F.A.C.P.; Milton G. Crane, M.D., F.A.C.P.; Varner J. Johns Jr., M.D., F.A.C.P.
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Two hundred eighty plasma renin activity (PRA) measurements were made in 100 patients with hypertension. Special attention was given to determining the usefulness of the PRA as a means of diagnosing primary aldosteronism and renovascular hypertension. Venous blood samples were obtained with the patients supine on liberal intake of sodium and, again, after the subject had been on 3 days of sodium restriction ( < 10 mEq Na+/24 hr) and had been standing upright for 4 hr. Plasma for PRA was prepared for analysis according to Boucher and associates and assayed in nephrectomized rats.
Forty-two patients (42%) had values that
Harris JJ, Crane MG, Johns VJ. Plasma Renin Activity in Hypertension.. Ann Intern Med. ;66:1036–1037. doi: 10.7326/0003-4819-66-5-1036_3
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Published: Ann Intern Med. 1967;66(5):1036-1037.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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