Baruch S. Blumberg, M.D., Ph.D., F.A.C.P.; Betty Jane S. Gerstley, M.D. (Associate); W. Thomas London, M.D.; Alton I. Sutnick, M.D., F.A.C.P.
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A "new" apparently inherited serum isoantigen, "Australia antigen" (Au(I)), which has not been found in the normal United States population, is present in high frequency in patient's with Down's syndrome and leukemia. Forty-five Down's syndrome patients, of whom 19 had Au(1) and 26 did not (Au(0)), and 10 control mentally retarded patients without Down's syndrome were included in this study.
Studies of their immunologic mechanisms revealed distinct differences between patients with and without Down's syndrome. These included lower influenza antibody titers, less reaction to the mumps skin test, and higher gamma-A immunoglobulin levels in Down's syndrome patients. Rebuck skin window
Blumberg BS, Gerstley BJS, London WT, et al. Down's Syndrome. Two Types Distinguished by a Serum Antigen (Australia Antigen).. Ann Intern Med. 1967;66:1040. doi: https://doi.org/10.7326/0003-4819-66-5-1040_2
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Published: Ann Intern Med. 1967;66(5):1040.
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