Joanne Jepson, M.D.; Henry Friesen, M.D.
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A commercial preparation of placental lactogen was found to increase the incorporation of 59Fe into the erythrocytes of hypoxia-induced plethoric mice and the red cell mass and plasma volume of normal mice after injection, daily, for 3 weeks. In order to rule out the possibility that the erythropoietic activity of this hormone was due to contamination with erythropoietin, a more purified placental lactogen preparation (Friesen, 1965), as well as other placental fractions obtained by fractionation on Sephadex G100, was tested in plethoric mice for erythropoietic activity. The dose response curve of placental lactogen was compared to that of known amounts
Jepson J, Friesen H. Comparison of the Erythropoietic Effect of Erythropoietin and Placental Lactogen.. Ann Intern Med. 1967;66:1042. doi: 10.7326/0003-4819-66-5-1042_2
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Published: Ann Intern Med. 1967;66(5):1042.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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