George M. Kalmanson, M.D., F.A.C.P.; Earl G. Hubert, M.A.; John Z. Montgomerie, M.B.; Lucien B. Guze, M.D.
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Reports have appeared of the isolation of "protoplasts" (osmotically fragile microbial forms in which the amount of cell wall remaining has not been determined) from patients with a variety of diseases. They have also been produced in rats with acute enterococcal pyelonephritis by treatment with penicillin. Although the exact role of these forms in the pathogenesis of disease remains undefined, it is possible that they could be responsible for disease by a variety of mechanisms. Some knowledge of the host-parasite relationship of these forms becomes important, and the present studies were designed to evaluate the effect of normal human serum
Kalmanson GM, Hubert EG, Montgomerie JZ, et al. Effect of Serum on Microbial Protoplasts.. Ann Intern Med. 1967;66:1046. doi: https://doi.org/10.7326/0003-4819-66-5-1046_3
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Published: Ann Intern Med. 1967;66(5):1046.
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