William F. Denny, M.D. (Associate); William J. Flanigan, M.D.
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Six patients undergoing preparation for renal transplantation were used in observing the effect of bilateral nephrectomy and splenectomy on erythropoietic mechanisms. All patients were chronically anemic, azotemic, and required periodic transfusions for maintenance of hematocrit levels of 20 to 22%. Simultaneous determinations of ferrokinetic data and red cell survival were carried out using a dual isotope technique. Erythropoietin assays were done by a bioassay using polycythemic mice and 59Fe. The effect of the patient's plasma on both exogenous and endogenous erythropoietin was assessed. Erythropoietin activity was absent before (0.37% ± 0.07 SE of the mean) and after nephrectomy (0.42% ±
Denny WF, Flanigan WJ. Studies of Erythropoiesis in Man Before and After Bilateral Nephrectomy.. Ann Intern Med. ;66:1049. doi: 10.7326/0003-4819-66-5-1049_2
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Published: Ann Intern Med. 1967;66(5):1049.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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