Robert C. Muehrcke, M.D., F.A.C.P.; Conrad L. Pirani, M.D.; Robert M. Kark, M.D., F.A.C.P.
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Serial clinicopathological observations were made on 76 patients with interstitial nephritis. Tissue was obtained by renal biopsy and studied, using light and electron microscopy. In addition, tissue was cultured for bacteria. Interstitial nephritis was divided into primary (40 patients studied) and secondary (36 patients studied). Primary interstitial nephritis was further subdivided into acute (8 patients) and chronic (32 patients).
Primary acute interstitial nephritis was associated with infection by brucellosis (2 patients) and syphilis (1 patient). The clinical features were massive proteinuria, azotemia, and progressive renal insufficiency. The striking morphology was diffuse interstitial edema, fibrosis, and cellular infiltrates. Acute renal failure
Muehrcke RC, Pirani CL, Kark RM. Interstitial Nephritis: A Clinicopathological Renal Biopsy Study.. Ann Intern Med. 1967;66:1052. doi: https://doi.org/10.7326/0003-4819-66-5-1052_1
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Published: Ann Intern Med. 1967;66(5):1052.
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