Russell E. Randall Jr., M.D., F.A.C.P.
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Acute renal failure may occur after kanamycin, bacitracin, polymyxin, and amphotericin. Recent observations with six others are listed.
Neomycin: Inadvertent injection of 4, 6, 8, and 72 g in four patients resulted in deafness in two, acute renal failure in one, and permanent renal insufficiency in one. Early treament with hemodialysis reduced serum neomycin concentrations rapidly in two, Kiil dialysance measuring 57 ml/min. Mannitol diuresis removed significant amounts in another while peritoneal dialysis was much less effective. These maneuvers probably prevented acute renal failure in two whose urine contained numerous tubular cell casts. These modes of emergency therapy to prevent
Randall RE. Renal Failure Following Antibiotics.. Ann Intern Med. 1967;66:1052–1053. doi: https://doi.org/10.7326/0003-4819-66-5-1052_2
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Published: Ann Intern Med. 1967;66(5):1052-1053.
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