Charles D. Swartz, M.D.; Kwan Kim, M.D.; Lionel Mailloux, M.D.; Albert N. Brest, M.D., F.A.C.P.
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Three patients with adequate urinary flows developed acute anuria after the therapeutic administration of low-molecular weight dextran (dextran 40). The apparent common clinical denominator for the three patients was renal ischemia. We elected to test the hypothesis that dextran 40 in the presence of renal hypoperfusion will produce tubular blockade and anuria.
Ten well-hydrated female mongrel dogs were studied. Bilateral ureteral catheters were placed, and the left renal artery was constricted to 50% of its initial diameter by a silk ligature. Urinary creatinine, para-aminohippuric acid concentrations, and osmolarity were always greater on the constricted side. After a period of equilibration
Swartz CD, Kim K, Mailloux L, et al. Acute Renal Shutdown Following Low Molecular Weight Dextran Infusion: Clinical and Experimental Experience.. Ann Intern Med. 1967;66:1054. doi: https://doi.org/10.7326/0003-4819-66-5-1054_1
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Published: Ann Intern Med. 1967;66(5):1054.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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