John D. Allen, M.D.
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Many humoral and mechanical factors have been implicated during the past 3 decades in the development of acquired emphysema. However, it has only been in recent years that Eriksson in Sweden has demonstrated that hereditary factors in the form of a serum deficiency of alpha-1 globulin and antitrypsin are associated with the development of obstructive pulmonary disease at an early age in adults. That this problem is not frequently recognized seems apparent since only two previous case reports have appeared in this country.
We have had the opportunity to see and follow the five patients presented in this report during
Allen JD. Six Cases of Inherited Deficiency of Serum Alpha1 Antitrypsin Associated with Premature Pulmonary Emphysema.. Ann Intern Med. 1967;66:1054–1055. doi: 10.7326/0003-4819-66-5-1054_3
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Published: Ann Intern Med. 1967;66(5):1054-1055.
Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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