William W. Faloon, M.D., F.A.C.P.; Dale I. Webb, M.D.; Thomas F. Race, M.D.
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Despite its historical role in gout, the metabolic effects of colchicine have not been explored. In six obese patients receiving constant low-calorie diets, containing 300 to 500 mg of cholesterol daily, colchicine, 1.9 to 3.9 mg/day orally, was administered for 4 to 21 days. Colchicine periods were preceded by 4- to 7-day control periods and were succeeded by postdrug periods of 4 to 8 days of the same diet, or 10 days of fasting. Serum cholesterol fell by 40 to 80 mg/100 ml in 6 days in four of the five patients. In one patient a fall of 20 mg/100
Faloon WW, Webb DI, Race TF. Cholesterol Lowering Effect of Colchicine.. Ann Intern Med. 1967;66:1058. doi: 10.7326/0003-4819-66-5-1058_3
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Published: Ann Intern Med. 1967;66(5):1058.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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