Samuel L. Hollobaugh, M.D.; Manuel Tzagournis, M.D.; Fred A. Kruger, M.D.; George J. Hamwi, M.D., F.A.C.P.
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Adipose tissue triglycerides supply most of the energy required for survival during starvation. Carbohydrate utilization under these conditions is very low. The mechanisms responsible for these changes are unclear.
U-19425 ("pyrazole") is an inhibitor of lipid mobilization. The availability of such a material prompted its use as an experimental tool to assess control mechanisms during total starvation.
Three obese patients were subjected to varying periods of starvation (9 to 30 days). Pyrazole was given to each for a portion of the fast. Administration of this compound acutely decreased the levels of plasma free fatty acids and ketones, which gradually returned
Hollobaugh SL, Tzagournis M, Kruger FA, et al. Studies on the Mechanisms of Adaptation to Starvation.. Ann Intern Med. 1967;66:1058–1059. doi: https://doi.org/10.7326/0003-4819-66-5-1058_4
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Published: Ann Intern Med. 1967;66(5):1058-1059.
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