Samuel L. Hollobaugh, M.D.; Manuel Tzagournis, M.D.; Fred A. Kruger, M.D.; George J. Hamwi, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
Adipose tissue triglycerides supply most of the energy required for survival during starvation. Carbohydrate utilization under these conditions is very low. The mechanisms responsible for these changes are unclear.
U-19425 ("pyrazole") is an inhibitor of lipid mobilization. The availability of such a material prompted its use as an experimental tool to assess control mechanisms during total starvation.
Three obese patients were subjected to varying periods of starvation (9 to 30 days). Pyrazole was given to each for a portion of the fast. Administration of this compound acutely decreased the levels of plasma free fatty acids and ketones, which gradually returned
Hollobaugh SL, Tzagournis M, Kruger FA, Hamwi GJ. Studies on the Mechanisms of Adaptation to Starvation.. Ann Intern Med. ;66:1058–1059. doi: 10.7326/0003-4819-66-5-1058_4
Download citation file:
Published: Ann Intern Med. 1967;66(5):1058-1059.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use