Herbert Gershberg, M.D., F.A.C.P.; Zenaida C. Javier, M.D.; Mildred M. Hulse, M.S.
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Approximately 45% of women taking oral contraceptives over 3 years have impaired glucose tolerance, and 85% have abnormal cortisone glucose tolerance. Five milligrams norethynodrel and 0.075 mg mestranol, 1 mg ethynodiol diacetate and 0.10 mg mestranol, and (sequential) 0.080 mg mestranol for 15 days and 0.080 mg mestranol and 2 mg chlormadinone acetate for 5 days—all produce these changes. The responsible component is the estrogen, and administration of 0.075 mg mestranol daily produces similar changes.
A reduction in insulin secretion is not the cause of the abnormalities since insulin secretion in response to glucose initially increases. The serum insulin binding
Gershberg H, Javier ZC, Hulse MM. Oral Contraceptives, Estrogen, and Carbohydrate Metabolism.. Ann Intern Med. 1967;66:1059. doi: https://doi.org/10.7326/0003-4819-66-5-1059_1
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Published: Ann Intern Med. 1967;66(5):1059.
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