Harold H. Sandstead, M.D.; Y. D. Coble Jr., M.D.; J. P. Carter, M.D.; Louis E. Grivetti, M.A.; Z. Farid, M.D.; A. R. Schulert, Ph.D.; V. N. Patwardhan, Ph.D.; W. J. Darby, M.D., F.A.C.P.; A. S. Prasad, M.D., F.A.C.P.; A. Miale Jr., M.D.
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Zinc, a ubiquitous cation in nature, is an integral part of at least nine metalloenzymes and plays an as yet undefined role in nucleic acid and protein synthesis. Deficiency of zinc in man may impair growth and delay puberty. The clinical features of extreme cases resemble idiopathic hypopituitarism. Specific abnormal endocrine function tests include low urinary excretion of pituitary gonadotropin and 17-ketosteroids. Base-line urinary 17-hydroxysteroids are usually normal, but pituitary adrenocorticotrophic hormone reserve assessed by metyrapone tests is decreased. Postinsulin plasma growth hormone levels are low. Intravenous glucose tolerance tests are normal; oral tests are compatible with impaired absorption of
Sandstead HH, Coble YD, Carter JP, et al. A Review of Studies on Human Zinc Deficiency by the Vanderbilt University Nutrition Group.. Ann Intern Med. 1967;66:1061–1062. doi: https://doi.org/10.7326/0003-4819-66-5-1061_2
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Published: Ann Intern Med. 1967;66(5):1061-1062.
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