Henry T. Lynch, M.D.; David E. Anderson, Ph.D.; Anne J. Krush, M.S.
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Approximately 250,000 deaths from cancer occur annually in the United States. Of these, an estimated 80,000 lives could be salvaged by earlier cancer detection. Hereditary forms of malignancies undoubtedly were present in a significant proportion of these patients. Had genetic knowledge for the predictability of malignancies in families been applied, many of these patients could have been offered a better prognosis. Such malignancies as Gardner's syndrome, retinoblastoma, familial polyposis coli, xeroderma pigmentosum, nevoid basal cell carcinoma syndrome, and neurofibromatosis show classic mendelian inheritance while others, including carcinoma of the breast, stomach, lung, and prostate, show a hereditary predisposition posing a
Lynch HT, Anderson DE, Krush AJ. Heredity and Cancer Control: Genetic Counseling.. Ann Intern Med. ;66:1065–1066. doi: 10.7326/0003-4819-66-5-1065_2
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Published: Ann Intern Med. 1967;66(5):1065-1066.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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