Thomas J. Pekin Jr., M.D. (Associate); Theodore I. Malinin, M.D.; Nathan J. Zvaifler, M.D., F.A.C.P.
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Synovial fluid analysis is recognized as an important part of the diagnostic work-up of the patient with arthritis. For the past 3 years we have examined several hundred synovial fluids from a variety of clinically well-defined conditions affecting joints. Systematic examination of synovial fluid includes white blood cell (WBC) count, search for presence of crystalline material, test for rheumatoid factor (RF), measurement of hemolytic complement (C) activity, examination of Feulgen-stained preparations for the presence of deoxyribonucleic acid (DNA) particles and Giemsa-stained preparations for the presence of macrophages.
The application of these methods to synovial fluid analysis resulted in the differentiation
Pekin TJ, Malinin TI, Zvaifler NJ. Clinical Value of Systematic Examination of Synovial Fluid.. Ann Intern Med. 1967;66:1068. doi: https://doi.org/10.7326/0003-4819-66-5-1068_2
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Published: Ann Intern Med. 1967;66(5):1068.
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