HOWARD DUNCAN, M.D.; BOY FRAME, M.D., F.A.C.P.; HAROLD M. FROST, M.D.; A. ROBERT ARNSTEIN, M.D.
Osteoporosis is most often a generalized disturbance and when confined to a local region usually results from inactivity of the affected part. The main causes for localized osteoporosis (osteolysis) include fracture or injury when a limb is immobilized by splints or traction, local joint disease sufficiently painful to cause voluntary immobilization, paralysis of the part due to neuromuscular deficit, reflex sympathetic dystrophy (Sudeck's atrophy or shoulder-hand syndrome), and autolysis of bone—at times referred to as "disappearing bone disease."
In this paper we describe three patients with a syndrome consisting of acute migratory and painful soft tissue swelling in the lower
DUNCAN H, FRAME B, FROST HM, ARNSTEIN AR. Migratory Osteolysis of the Lower Extremities. Ann Intern Med. ;66:1165–1173. doi: 10.7326/0003-4819-66-6-1165
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Published: Ann Intern Med. 1967;66(6):1165-1173.
Endocrine and Metabolism, Hospital Medicine, Lupus Erythematosus, Metabolic Bone Disorders, Rheumatology.
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