KENNETH M. MOSER, M.D., F.A.C.P.; GEORGE C. HAJJAR, M.D.
The medical subspecialist may become so familiar with certain phenomena in his area of interest that he may drift into the assumption that these phenomena are common knowledge among his colleagues. Such an assumption often inhibits, quite unintentionally, the dissemination of clinically important information to the practicing physician. This report deals with one such situation: the effect of heparin on the one-stage prothrombin time. As will be documented here, prolongation of the prothrombin time by heparin introduces a frequently unrecognized variable into the proper establishment and maintenance of anticoagulant therapy with prothrombinopenic (coumarin-type) agents.
Our interest in this problem was
MOSER KM, HAJJAR GC. Effect of Heparin on the One-Stage Prothrombin Time: Source of Artifactual "Resistance" to Prothrombinopenic Therapy. Ann Intern Med. ;66:1207–1213. doi: 10.7326/0003-4819-66-6-1207
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Published: Ann Intern Med. 1967;66(6):1207-1213.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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