LEON D. OSTRANDER JR., M.D., F.A.C.P.; BEVERLY J. NEFF, PH.D.; WALTER D. BLOCK, PH.D.; THOMAS FRANCIS JR., M.D., SC.D.; FREDERICK H. EPSTEIN, M.D.
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Coronary heart disease has been associated with a number of physiologic abnormalities, of which hypertension and hypercholesterolemia have been most clearly defined as risk factors.
Regardless of the mechanism of atheroma formation high serum levels of cholesterol or other lipid fractions would be expected to accelerate atherogenesis. This relationship is supported by a great deal of epidemiologic evidence (1-3).
High levels of blood glucose are also found with significant frequency among persons with atherosclerosis (4-6), but it is difficult to rationalize a direct relationship between an abnormality in carbohydrate metabolism and the development of atheroma, which consist largely of lipid
OSTRANDER LD, NEFF BJ, BLOCK WD, et al. Hyperglycemia and Hypertriglyceridemia Among Persons with Coronary Heart Disease. Ann Intern Med. 1967;67:34–41. doi: 10.7326/0003-4819-67-1-34
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Published: Ann Intern Med. 1967;67(1):34-41.
Cardiology, Coronary Heart Disease, Coronary Risk Factors, Dyslipidemia.
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