JOHN H. FELTS, M.D., F.A.C.P.; JOHN R. NELSON, M.D.; C. NASH HERNDON, M.D.; CHARLES L. SPURR, M.D., F.A.C.P.
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Hemochromatosis is characterized by increased absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in body organs. Sheldon's postulation (1) that the process is an inborn error of iron metabolism has been challenged directly and indirectly in the past 30 years, and a number of other factors favoring iron overload have been distinguished, among them excessive intake, whether drug (2), dietary (3), or transfusion (4); increased absorption secondary to pancreatic insufficiency (5) or portacaval shunts (6); heavy consumption of alcohol and cirrhosis of the liver (3); and accelerated erythrocyte destruction with impaired iron reutilization (4). Only 1
FELTS JH, NELSON JR, HERNDON CN, et al. Hemochromatosis in Two Young Sisters: Case Studies and a Family Survey. Ann Intern Med. 1967;67:117–123. doi: 10.7326/0003-4819-67-1-117
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Published: Ann Intern Med. 1967;67(1):117-123.
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