GEORGE D. LUDWIG, M.D., F.A.C.P.; LOUIS B. CHAYKIN, M.D.; ANTONIO V. ESCUETA, M.D.
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A syndrome of cerebral gigantism with normal sella turcica occurring in childhood has recently been described by Sotos and co-workers (1). In all of their patients the growth spurt leading to gigantism appeared to take place during the first 4 years of life, probably beginning before birth, since the birth length was between the ninetieth and the ninety-seventh percentiles in all and the birth weight was between these percentiles in three of the five cases. These children displayed acromegalic features and a nonprogressive cerebral disorder with mental retardation. Two of the five had convulsive seizures.
A somewhat similar syndrome, consisting
LUDWIG GD, CHAYKIN LB, ESCUETA AV. Cerebral Gigantism with Intermittent Fractional Hypopituitarism and Normal Sella Turcica. Ann Intern Med. 1967;67:123–131. doi: 10.7326/0003-4819-67-1-123
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Published: Ann Intern Med. 1967;67(1):123-131.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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