CALVIN M. KUNIN, M.D., F.A.C.P.
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The complexity of antimicrobial therapy has increased as new drugs and the analogues of older agents have grown in number. Clinical practice has also been complicated by the necessity to use potentially toxic drugs in patients with diseases of the liver or the kidney, or both. Numerous reports are available in the literature concerning the alteration of the fate of antimicrobial agents in the presence of disease of these organs, but they are not always readily available when the information is required for immediate therapeutic decisions.
This report contains a compilation of the currently available data on factors that determine
KUNIN CM. A Guide to Use of Antibiotics in Patients with Renal Disease: A Table of Recommended Doses and Factors Governing Serum Levels. Ann Intern Med. 1967;67:151–158. doi: https://doi.org/10.7326/0003-4819-67-1-151
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Published: Ann Intern Med. 1967;67(1):151-158.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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