SOLOMON POSEN, M.D., F.R.A.C.P.
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The term alkaline phosphatase (International Enzyme Classification 3:1:3:1 (I)) is applied to a group of enzymes sharing the capacity to hydrolyze phosphate esters in an alkaline medium. Since the first1 description of a phosphatase by Suzuki, Yoshimura, and Takaishi (2) in 1907 the subject has been repeatedly reviewed (4-16), and this article surveys some of the progress in our knowledge of this group of enzymes made since the appearance of Gutman's (15) comprehensive paper. Particular emphasis will be placed on those advances with a direct bearing on clinical medicine.
In spite of many attempts to prove the existence of
POSEN S. Alkaline Phosphatase. Ann Intern Med. ;67:183–203. doi: 10.7326/0003-4819-67-1-183
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Published: Ann Intern Med. 1967;67(1):183-203.
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