GEORGE R. GREEN, M.D.; GUSTAVUS A. PETERS, M.D., F.A.C.P.; JOSEPH E. GERACI, M.D., F.A.C.P.
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A major problem in present-day management of bacterial endocarditis is the choice of optimal antibiotic therapy in patients who give a history of allergy to penicillin. Bacterial endocarditis was invariably fatal before the discovery of penicillin. Even today the mortality remains around 20 to 30%. Penicillin alone, or as part of combined therapy, remains the preferred treatment in most instances since it is bactericidal and experience has proved it to be effective (1). This is especially true for enterococcal endocarditis, in which administration of penicillin G and streptomycin as combined therapy has been necessary in most instances (2).
GREEN GR, PETERS GA, GERACI JE. Treatment of Bacterial Endocarditis in Patients with Penicillin Hypersensitivity. Ann Intern Med. ;67:235–249. doi: 10.7326/0003-4819-67-2-235
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Published: Ann Intern Med. 1967;67(2):235-249.
Cardiology, Endocarditis, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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