ROBERT S. BROWN, M.D.; HARLEY A. HAYNES, M.D.; H. THOMAS FOLEY, M.D.; HERMAN A. GODWIN, M.D.; COSTAN W. BERARD, M.D.; PAUL P. CARBONE, M.D.
This content is PDF only. Please click on the PDF icon to access.
Impaired delayed hypersensitivity (1-9) and prolonged skin homograft rejection (8-11) have been demonstrated in patients with Hodgkin's disease, even in those with localized involvement and in good clinical condition. Defective lymphocyte function has been implicated as the cause of the immunologic abnormalities (12-14). In patients with extensive disease, lymphocytopenia may contribute to further impairment (2, 15). A defect in antibody response to primary antigens has been observed, although less consistently than impaired delayed hypersensitivity (5, 16-19). These deficiencies might be responsible for the increased susceptibility of patients with Hodgkin's disease to certain viral and fungal infections (20, 21).
BROWN RS, HAYNES HA, FOLEY HT, et al. Hodgkin's Disease: Immunologic, Clinical, and Histologic Features of 50 Untreated Patients. Ann Intern Med. 1967;67:291–302. doi: 10.7326/0003-4819-67-2-291
Download citation file:
Published: Ann Intern Med. 1967;67(2):291-302.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use