HARVEY E. GOLDEN, M.D.; FREDERIC C. MCDUFFIE, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
Since the original description of the lupus erythematosus (LE) cell by Hargraves, Richmond, and Morton (1), it has become clear that this inclusion-containing cell is formed in two stages (2, 3). In the first stage an abnormal gamma G globulin, the LE factor, reacts with a component of the nucleus, apparently the deoxyribonucleic acid-histone complex (4), to form nuclear material that is altered in appearance. This altered nuclear material may then be phagocytized in the second stage to form LE cells, or it may remain extracellular. This altered extracellular nuclear material (ECM) (5) takes several forms, the most commonly recognized
GOLDEN HE, MCDUFFIE FC. Role of Lupus Erythematosus Factor and Accessory Serum Factors in Production of Extracellular Nuclear Material. Ann Intern Med. 1967;67:780–790. doi: 10.7326/0003-4819-67-4-780
Download citation file:
Published: Ann Intern Med. 1967;67(4):780-790.
Lupus Erythematosus, Rheumatology.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use