OTO KÜCHEL, M.D., SC.D.; LAWRENCE M. FISHMAN, M.D.; GRANT W. LIDDLE, M.D., F.A.C.P.; ANDREW MICHELAKIS, M.D., PH.D.
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Suppression of renin production is a characteristic of primary aldosteronism; therefore, measurement of plasma renin activity has been proposed as a procedure for screening hypertensive patients for this disorder. In using plasma renin levels to distinguish primary aldosteronism from other hypertensive diseases, Conn, Cohen, Rovner, and Nesbit (1) have recommended that patients receive low-sodium diets for several days and then assume upright posture for several hours before obtaining the crucial blood sample. In normal subjects sodium depletion and upright posture both stimulate renin production. In patients with primary aldosteronism, however, plasma renin activity remains relatively low despite the application of
KÜCHEL O, FISHMAN LM, LIDDLE GW, et al. Effect of Diazoxide on Plasma Renin Activity in Hypertensive Patients. Ann Intern Med. 1967;67:791–799. doi: https://doi.org/10.7326/0003-4819-67-4-791
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Published: Ann Intern Med. 1967;67(4):791-799.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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