ENRIQUE ROMERO, M.D.
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To the Editor: In the article "A Guide to the Use of Antibiotics in Patients with Renal Disease," which appeared in the July (1967) issue of the ANNALS, the author states that a compound recovered only in small amounts in the urine would be expected to be rapidly metabolized or excreted by another pathway and not to accumulate in patients with renal disease.
Also, in the last edition of Goodman and Gilman's textbook of pharmacology, p. 1250, it reads: "In patients with renal insufficiency who require therapy with this class of antibiotic (tetracyclines), the dosage should be reduced and, preferably,
ROMERO E. CHLORTETRACYCLINE IN UREMIA. Ann Intern Med. ;67:907–908. doi: 10.7326/0003-4819-67-4-907_3
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Published: Ann Intern Med. 1967;67(4):907-908.
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