LESLIE J. DEGROOT, M.D.; VINCENT PERLO, M.D.; THOMAS GEPHART, M.D.; ROBERT SCHWAB, M.D.
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That the thymus and the thyroid are closely related has been evident, at least on anatomical grounds, for 5 decades. Enlargement of the thymus in Graves' disease prompted Crotti (1) to do combined thymectomy and thyroidectomy on large numbers of patients. In 1922 this author reported the operation to be the "procedure of choice" for childhood Graves' disease. After years of desuetude interest has now again focused on the thymus. A possible autoimmune factor has been found in Graves' disease (2), the long-acting thyroid stimulator (LATS), identified tentatively as a 7S gamma globulin. Further, the thymus in Graves' disease is
DEGROOT LJ, PERLO V, GEPHART T, et al. Remission of Myasthenia and Thyrotoxicosis After Thymectomy. Ann Intern Med. 1967;67:1042–1044. doi: https://doi.org/10.7326/0003-4819-67-5-1042
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Published: Ann Intern Med. 1967;67(5):1042-1044.
DOI: 10.7326/0003-4819-67-5-1042
Endocrine and Metabolism, Thyroid Disorders.
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