SHELDON M. WOLFF, M.D., F.A.C.P.; HARRY R. KIMBALL, M.D.; SEYMOUR PERRY, M.D., F.A.C.P.; RICHARD ROOT, M.D.; ATTALLAH KAPPAS, M.D., F.A.C.P.
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Dr. Sheldon M. Wolff: In 1956 Dr. Attallah Kappas and Hellman, Fukushima, and Gallagher (1) first reported that the steroid metabolite etiocholanolone caused fever when it was administered to man. Subsequent work by the same investigators and others has substantiated the pyrogenic properties of etiocholanolone (2) and other 5 beta-H C19, C21, and C24 steroids (3). These observations are especially noteworthy since they describe biologic activity possessed by a class of compounds previously thought to be physiologically inert and since they represent the first discovery of pyrogenic substances of endogenous origin in man. Interest in etiocholanolone was heightened considerably by
WOLFF SM, KIMBALL HR, PERRY S, ROOT R, KAPPAS A. The Biological Properties of Etiocholanolone: Combined Clinical Staff Conference at the National Institutes of Health. Ann Intern Med. ;67:1268–1295. doi: 10.7326/0003-4819-67-6-1268
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Published: Ann Intern Med. 1967;67(6):1268-1295.
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