M. DAVID POSNER, M.D.
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To the Editor: This letter is in reference to the following article: EYSTER, M. E.: Melphalan (Alkeran®) erythrocyte agglutinin and hemolytic anemia. Ann. Intern. Med. 66: 573, 1967.
The designation "autoimmune" disease has been applied to a large number of disease entities, all of which have in common the fact that endogenous protein molecule combines with host tissue. This fact, however, as I have related it, does not distinguish between autoimmune and what might be termed autoserologic states. The distinguishing characteristic of the immune state is that endogenous protein production is "stimulated"—in direct response to the presence of antigen. Admittedly,
POSNER MD. AUTOIMMUNE VERSUS AUTOSEROLOGIC. Ann Intern Med. ;67:1350. doi: 10.7326/0003-4819-67-6-1350_1
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Published: Ann Intern Med. 1967;67(6):1350.
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