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Although a direct reference to the "cascade" or "waterfall" theory of coagulation is made only in the notes after the main text, the theme appears to be a presentation of an alternate coagulation scheme. Both schemes place central importance on the function of activated factor X (factor Xa), called autoprothrombin C by the author, as the enzyme that converts prothrombin to thrombin. However, the author considers the plasma clotting factors VII, IX, and X, as described by others, to be only hypothetical substances. Rather, their activities in the clotting process are performed by products of prothrombin degradation (called autoprothrombin IP,
Prothrombin in Enzymology, Thrombosis and Hemophilia.. Ann Intern Med. 1967;67:1356–1357. doi: https://doi.org/10.7326/0003-4819-67-6-1356_2
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Published: Ann Intern Med. 1967;67(6):1356-1357.
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