R. F. BOHNEN, M.D.; J. E. ULTMANN, M.D., F.A.C.P.; J. G. GORMAN, M.D.; M. FARHANGI, M.D.; J. SCUDDER, M.D., D. MED. SC.
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Over a 13-year period 178 patients were discovered to have a positive direct Coombs' test. A wide range of disease conditions, including collagen disorders, leukemia, lymphoma, and cancers, was found. In addition, several diseases infrequently associated with a positive direct Coombs' reaction were encountered, including pernicious anemia, ulcerative colitis, and demyelinating disorders of the central nervous system. Two patients had previously unreported findings: Coombs'-positive hemolytic anemia after amphotericin B administration and Evans' syndrome with a spontaneously occurring anti-S antibody. Cases of interest are summarized and discussed. A significant number of these patients had anemia, hepatosplenomegaly, and various serum protein abnormalities. Half of these patients had previous transfusions. The possible significance of transfusion in the production of the positive Coombs' reaction is discussed.
BOHNEN RF, ULTMANN JE, GORMAN JG, et al. The Direct Coombs' Test: Its Clinical Significance: Study in a Large University Hospital. Ann Intern Med. 1968;68:19–32. doi: 10.7326/0003-4819-68-1-19
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Published: Ann Intern Med. 1968;68(1):19-32.
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