LARRY A LINDESMITH, M.D.; R. DIXIE BAINES JR., M.D.; D. BOYD BIGELOW, M.D.; THOMAS L. PETTY, M.D.
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Respiratory paralysis is a potentially fatal, though reversible, complication of the use of polymyxin B and colistimethate (polymyxin E) in patients with renal disease. Clinical findings in 11 cases of reversible respiratory paralysis associated with polymyxin therapy are reviewed and their management discussed. A relationship between the neuromuscular toxicity of these drugs and underlying renal disease is emphasized. Previously reported cases in the literature are summarized, and possible mechanisms producing neuromuscular blockade are discussed.
LINDESMITH LA, BAINES RD, BIGELOW DB, PETTY TL. Reversible Respiratory Paralysis Associated with Polymyxin Therapy. Ann Intern Med. ;68:318–327. doi: 10.7326/0003-4819-68-2-318
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Published: Ann Intern Med. 1968;68(2):318-327.
Neurology, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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