Howard J. Schwartz, M.D.; Francis C. Lowell, M.D., F.A.C.P.; James C. Melby, M.D.
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Relative resistance to corticosteroid therapy was observed in some asthmatic patients. The eosinopenic responses to 40 mg cortisol intravenously in 19 unselected asthmatics (group A) and 6 resistant asthmatics (group B) were measured by following changes in total eosinophil counts (TEC). The percent TEC changes were -35, -77, and -73 in group A and -10, -36, and +5 in group B at 2, 4, and 6 hr after administration. These differences were highly significant (P = 0.01) and independent of the base-line TEC.
Cortisol turnover studies in four subjects from each group were done. Each patient received a tracer dose
Schwartz HJ, Lowell FC, Melby JC. Steroid Resistance in Bronchial Asthma.. Ann Intern Med. 1968;68:1141. doi: https://doi.org/10.7326/0003-4819-68-5-1141_3
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Published: Ann Intern Med. 1968;68(5):1141.
Asthma, Pulmonary/Critical Care.
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