M. Henry Gault, M.D., F.A.C.P.; John B. Dossetor, M.D., F.A.C.P.; Dennis Engles, M.D.; Christopher T. Rudwal, M.D.
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The symptom complex of psychiatric disorder, headache, peptic ulcer, anemia, and nephropathy may be considered a syndrome of analgesic abuse.
Of 22 patients developing serious impairment of renal function associated with the daily ingestion of analgesics, 17 had taken 5 or more tablets of a phenacetin-salicylate-caffeine-codeine preparation daily for 5 or more years. The typical patient was female (15), had suffered with headaches for many years (19), had received psychiatric investigation or treatment (18), and had had episodes of dyspepsia or upper gastrointestinal bleeding leading to gastrectomy before the diagnosis of renal disease (12). Peptic ulcer had been present in
Gault MH, Dossetor JB, Engles D, et al. Syndrome of Analgesic Abuse.. Ann Intern Med. 1968;68:1142. doi: https://doi.org/10.7326/0003-4819-68-5-1142_2
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Published: Ann Intern Med. 1968;68(5):1142.
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