Sanford R. Mallin, M.D. (Associate)
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Two sisters, 16 and 17 years old, were seen initially because of primary amenorrhea and absence of sexual development. In a subsequent 18-month period each girl presented with an acute surgical abdomen, and a hemorrhagic twisted cystic ovary was removed from each girl. At the time of surgery in each case, the "unaffected" ovary was enlarged, firm, polycystic, and sclerotic, and a biopsy showed diminished ovarian stroma with occasional primordial follicles and small follicular cysts but no further maturation. The younger sister subsequently developed a second acute abdomen, and her remaining ovary showed identical twisted, hemorrhagic cysts and was removed.
Mallin SR. Congenital Adrenal Hyperplasia Secondary to 17-Hydroxylase Deficiency Presenting as Amenorrhea, Hypokalemia, Hypertension, and Cystic Ovaries.. Ann Intern Med. 1968;68:1144. doi: https://doi.org/10.7326/0003-4819-68-5-1144_2
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Published: Ann Intern Med. 1968;68(5):1144.
DOI: 10.7326/0003-4819-68-5-1144_2
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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