Harry Kopelman, M.D., F.R.C.P.
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Early in 1965 an outbreak of jaundice occurred in Epping and in the surrounding area, affecting at least 84 people. The outbreak was traced to a special whole meal bread, the flour of which was contaminated in transit by 4.4′ diaminodiphenylmethane, an epoxy resin hardener. The epidemiology and investigation proved conclusively the cause and spread of the disease.
The clinical presentation was unusual and unlike that of other varieties of toxic jaundice. Fifty-seven patients had biochemical investigations that showed a varied picture, and eight aspiration liver biopsies were taken from seven patients. The pathological changes were likewise distinctive and unique
Kopelman H. The Epping Jaundice.. Ann Intern Med. 1968;68:1148. doi: https://doi.org/10.7326/0003-4819-68-5-1148_2
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Published: Ann Intern Med. 1968;68(5):1148.
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