George P. Canellos, M.D.; Robert T. Eagan; Jacqueline Whang, M.D.; Paul P. Carbone, M.D.
This content is PDF only. Please click on the PDF icon to access.
The Philadelphia (Ph1) chromosome in chronic granulocytic leukemia (CGL) is the only specific cytogenetic defect in human neoplastic disease. Attempts to demonstrate a definite biochemical lesion associated with this abnormality have not, as yet, been successful. Out of a group of 180 consecutive patients admitted to National Cancer Institute with clinical and hematologic features of CGL, 20 (12%) PH1-negative adults were studied. The mean age, sex distribution, and presenting symptomatology did not differ significantly from those of the larger PH1-positive group. One patient had leukemia cutis. The majority (15 of 20) had splenomegaly of some degree. There was a higher
Canellos GP, Eagan RT, Whang J, et al. Clinical Significance of the Philadelphia Chromosome in Chronic Granulocytic Leukemia.. Ann Intern Med. 1968;68:1166. doi: https://doi.org/10.7326/0003-4819-68-5-1166_2
Download citation file:
Published: Ann Intern Med. 1968;68(5):1166.
Results provided by:
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use