Kenneth S. Graff; Charles E. Mengel, M.D., F.A.C.P.; Stanley P. Balcerzak, M.D.
This content is PDF only. Please click on the PDF icon to access.
In vitro lysis of paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes presumably results from the unique interaction between these cells and the third component (C′3) of complement without the requirement for antibody and early phase reactants (C′1, C′4, C′2). Since various aromatic amino acid derivatives had been shown to inhibit C′3 in other systems, we examined the effects of some tryptophan metabolites on the HAM acid-serum lysis and the sucrose lysis tests of natural PNH and glutathione (GSH)-treated erythrocytes. Our previous studies had shown GSH-treated red cells to be indistinguishable from those of PNH patients. A range of 0 to 99% inhibition
Graff KS, Mengel CE, Balcerzak SP. Inhibition of in Vitro Paroxysmal Nocturnal Hemoglobinuria Lysis by Tryptophan Metabolites.. Ann Intern Med. ;68:1168. doi: 10.7326/0003-4819-68-5-1168_1
Download citation file:
Published: Ann Intern Med. 1968;68(5):1168.
Hematology/Oncology, Red Cell Disorders.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use