Arthur Copek; Robert C. Muehrcke, M.D., F.A.C.P.; Anil Mandal, M.D.; Samuel Gotoff, M.D.
This content is PDF only. Please click on the PDF icon to access.
Unilateral renal vein thrombosis produces massive proteinuria and in time the nephrotic syndrome. Bilateral membranous glomerulonephritis and subsequent progressive renal failure may develop as sequels. Serial clinicopathological studies were designed to investigate the pathogenesis of membranous glomerulonephritis due to renal vein occlusion.
The pathogenesis and evolution of renal lesions were studied in three patients by serial renal biopsies using light, electron, and immunomicroscopy. Tissue fixed for electron microscopy was cut at 0.5 µ, stained with methylene blue-azure II, and quantitatively analyzed. Individual glomerular cells were counted. Glomerular, Bowman's, and tubular basement membrane thicknesses were measured by electron microscopic analysis.
Copek A, Muehrcke RC, Mandal A, Gotoff S. An Autoantibody Mechanism for Membranous Glomerulonephritis Due to Renal Vein Obstruction.. Ann Intern Med. ;68:1179–1180. doi: 10.7326/0003-4819-68-5-1179_3
Download citation file:
Published: Ann Intern Med. 1968;68(5):1179-1180.
Autoimmune Kidney Disease, Nephrology, Rheumatology.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use