Margaret E. Todd, Ph.D.; Jaime Borrero, M.D.; E. Lovell Becker, M.D., F.A.C.P.
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In certain renal disease there is sufficient evidence of alterations in clotting to prompt a systematic study of the coagulation factors.
Thirty patients with the nephrotic syndrome from diverse causes, ten of whom had renal insufficiency, were studied. Renal biopsies were performed and stained with hematoxylin and eosin, periodic acid-Schiff reaction, Masson, silver methenamine, and Lendrum's MSB fibrin stain. Coagulation tests included prothrombin time, fibrinogen concentration, thromboplastin generation, heparin tolerance, platelet adhesive index, thromboelastography, bleeding time, and factor VIII assay.
In a significant number of patients there was fibrin noted within the glomerulus, and in the patient with the nephrotic
Todd ME, Borrero J, Becker EL. Renal Disease and Coagulation Alterations.. Ann Intern Med. 1968;68:1183–1184. doi: https://doi.org/10.7326/0003-4819-68-5-1183_4
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Published: Ann Intern Med. 1968;68(5):1183-1184.
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