Roger Williams, M.D.
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Two currently controversial aspects of hemochromatosis are the role of increased iron absorption in its pathogenesis and the value of venesection therapy in its treatment.
The results of 70 measurements in 40 patients showed that absorption was usually normal at the time of presentation although it increased rapidly during venesection therapy. After completion of treatment a wide range of values was found that could be related to the variable rate of reaccumulation of iron stores. The differential ferrioxamine test, which measures chelatable body iron, proved valuable in assessing such changes. Approximately a half of affected relatives had an increased iron
Williams R. Studies on the Pathogenesis and Treatment of Idiopathic Hemochromatosis.. Ann Intern Med. 1968;68:1191. doi: https://doi.org/10.7326/0003-4819-68-5-1191_2
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Published: Ann Intern Med. 1968;68(5):1191.
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