VARDAMAN M. BUCKALEW JR., M.D.
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It is now well-established that the syndrome of renal tubular acidosis (RTA), in which the primary defect is an inability to lower urinary pH normally, occurs as a familial disease in a small percentage of cases. However, the mode of transmission is not entirely clear. In a recent review, Seldin and Wilson (1) summarized the evidence in 14 families suggesting that familial RTA is due to an autosomal dominant gene. The strongest evidence favoring this view is found in the two families originally reported by Pitts, Schulte, and Smith (2) and subsequently by Randall and Taggart (3) and by Schreiner,
BUCKALEW VM. Familial Renal Tubular Acidosis. Ann Intern Med. 1968;68:1367–1368. doi: https://doi.org/10.7326/0003-4819-68-6-1367
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Published: Ann Intern Med. 1968;68(6):1367-1368.
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