WILLIAM L. KOPP, M.D.; JERRY S. TRIER, M.D.; E. RICHARD STIEHM, M.D.; PARVIZ FOROOZAN, M.D.
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An adult man with recurrent bacterial infections, joint symptoms, and diarrhea had unusually severe immunologic deficiency and clinical and histologic evidence of both rheumatoid arthritis and ulcerative colitis. Studies revealed absent immune globulins, defective delayed hypersensitivity, and low lymphocyte counts. He rejected an allograft gradually over a 2-month period while he took 15 mg of prednisone daily for colitis. In tissue culture his lymphocytes did not proliferate with phytohemagglutinin or with antigens, although they responded to allogeneic cells. At necropsy, only microscopic remnants of thymus were found.
The patient's illness, therefore, had characteristics of both "acquired" and lymphopenic agammaglobulinemia.
KOPP WL, TRIER JS, STIEHM ER, et al. "Acquired" Agammaglobulinemia with Defective Delayed Hypersensitivity. Ann Intern Med. 1968;69:309–317. doi: 10.7326/0003-4819-69-2-309
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Published: Ann Intern Med. 1968;69(2):309-317.
Diarrhea, Gastroenterology/Hepatology, Infectious Disease, Inflammatory Bowel Disease, Rheumatoid Arthritis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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