CALVIN M. KUNIN, M.D.
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A table summarizing recommended doses and factors governing serum levels of antimicrobial agents in patients with renal disease was published last year in the ANNALS (1). Since then, more information has been provided on the fate of gentamycin, nitrofurantoin, chloramphenicol, and colistin in the presence of renal disease.
Gentamycin is closely related to the aminoglycoside antibiotics streptomycin, neomycin, and kanamycin and has shown promise for use in patients with serious gram negative infections including those due to Pseudomonas. It also has activity against many gram positive organisms.
The most serious adverse effect is severe damage to vestibular function seen most
KUNIN CM. More on Antimicrobials in Renal Failure. Ann Intern Med. ;69:397–398. doi: 10.7326/0003-4819-69-2-397
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Published: Ann Intern Med. 1968;69(2):397-398.
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