CHARLES M. SHAPIRO, M.D., F.A.C.P.
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To the Editor: I was very interested in the article entitled "Thrombocytopenia and Symmetrical Peripheral Gangrene Associated with Staphylococcal and Streptococcal Bacteremia," by Rahal, MacMahon, and Weinstein (Ann. Intern. Med. 69: 35, 1968). In their discussion as to the cause of this phenomenon, they mention the possibility of staphylococcal toxin-producing platelet damage and aggregation and potentiating the formation of fibrinogen to fibrin. However, they do not stress the possible pathogenetic significance of intravascular coagulation in these cases. This may be especially significant since two of the three patients had definite hemolytic anemia, and the plasma of the patient in Case
SHAPIRO CM. GANGRENE AND BACTEREMIA. Ann Intern Med. ;69:845–846. doi: 10.7326/0003-4819-69-4-845_2
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Published: Ann Intern Med. 1968;69(4):845-846.
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